In Manhattan, the company was initially located in the Presbyterian building at 156 Fifth Avenue and, during the 1920s, at 449 Fourth Avenue.
In 1903, Cupples & Leon collected such strips as The Katzenjammer Kids. Alphonse and Gaston, Happy Hooligan, On and Off the Ark, Poor Lil Mose and The Tigers. Their major competitor in books of comic strip reprints was Frederick A. Stokes, who died in 1939.
They left the comic strip reprint field in 1934, concentrating on their juvenile fiction lines. The Platt & Munk publishing firm acquired Cupples & Leon in 1956.
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