The issue is the first published appearance of Josie James and Melody Jones, later of "Josie and the Pussycats" fame. Some sources claim the first appearance was a story in Archie's Pals and Gals #23 (Winter 1962-1963). However, the copyright records do not bear this out. She's Josie #1 was published on December 10, 1962; Archie's Pals and Gals #23 was published on December 17.
Josie, Melody and Pepper had been created by Dan DeCarlo for a proposed newspaper strip called "Here's Josie." when it didn't sell as a strip, he took the characters to Archie Comics and got the go-ahead to do it as a comic book.
Using the three girls as the foundation for the new comic, DeCarlo developed the characters and their supporting cast in conjunction with writer Frank Doyle. DeCarlo told TheTrades.com in 2001 that "I designed all the characters, and Frank Doyle was doing all the writing."